SARS-CoV-2 removal by mix matrix membrane: A novel application of artificial neural network based simulation in MATLAB for evaluating wastewater reuse risksArticle Published on 2023-01-012022-11-15 Journal: Chemosphere [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] artificial Artificial neural network collected COVID-19 COVID-19 outbreak demonstrated detect filtration Fractions include Iran Log reduction Mashhad MATLAB membrane Mix matrix membrane moderate outbreak plant polycarbonate prevalence rate recorded reduce reuse risk robust RT-qPCR SARS-CoV-2 specimen treated Treatment virus was collected wastewater wastewater treatment. [DOI] 10.1016/j.chemosphere.2022.136837 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 특이적 T 세포 및 항체, 코로나바이러스 질병 2019(COVID-19) 보호: 전향적 연구Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed antibody Antibody Response Antibody responses CD4+ CD8+ T cell CD8+ T cells clinical comparable coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlated COVID-19 demonstrated ELISPOT enzyme enzyme-linked immunosorbent evaluated flow cytometry followed by fraction Fractions frequencies Frequency healthcare highest IFN-γ IgG immune immune response Immunoglobulin Immunoglobulin G immunoglobulin M individual Infection interferon gamma interleukin interleukin 2 Kaplan-Meier estimator membrane nucleocapsid pandemic positive Probability Prospective PROTECT protective effect question Registration respiratory response SARS-CoV-2 SARS-COV-2 infection Spike protein Spike proteins staining T cell T cells T-cell T-cell and antibody responses T-cell Response T-cell responses the SARS-CoV-2 virus virus-specific antibodies Virus-specific IgG were infected with infection [DOI] 10.1093/cid/ciac278 PMC 바로가기 [Article Type] Article
Effect of treatment interruptions and outcomes in cancer patients undergoing radiotherapy during the first wave of COVID-19 pandemic in a tertiary care instituteObservational Study Published on 2022-07-042022-10-05 Journal: Journal of the Egyptian National Cancer Institute [Category] 임상, [키워드] Analysis Cancer cancer patient Care clinically cohorts of patients Comorbidities conducted COVID-19 COVID-19 pandemic COVID-19 patient disease Disease progression Effect effect of treatment eligible patient First wave Follow-up fraction Fractions general condition Immunosuppression impacted India less material Observational cohort study outcome outcomes Patient patients patients died patients treated positive Primary outcome Radiation radiation therapy Radiotherapy recovering from COVID-19 reported retrospective significant difference the patient Treatment Treatment interruption Treatment outcome Treatment outcomes. two groups [DOI] 10.1186/s43046-022-00129-0 PMC 바로가기 [Article Type] Observational Study
Association Between Total Cell Free DNA and SARS-CoV-2 In Kidney Transplant Patients: A Preliminary StudyArticle Published on 2022-07-012022-11-15 Journal: Transplantation proceedings [Category] COVID19(2023년), SARS, 바이오마커, [키워드] association Biomarker blood sample cell-free DNA cellular cfDNA collected COVID-19 COVID-19 diagnosis COVID-19 severity Cutoff DNA elevated examined Follow-up fraction Fractions Free high risk Hospitalized identify immune response Immunosuppression Infection Interpretation lowering median patients patients with COVID-19 positive R 2 raise recipient rejection reported Retrospective analysis risk SARS-CoV-2 severe COVID-19 significant decrease subset the median Total Transplant Two patient with COVID-19 [DOI] 10.1016/j.transproceed.2022.02.027 PMC 바로가기
Gelatin Stabilizes Nebulized Proteins in Pulmonary Drug Delivery against COVID-19젤라틴은 COVID-19에 대한 폐 약물 전달에서 분무된 단백질을 안정화합니다Article Published on 2022-06-132022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition Aerogen airway angiotensin angiotensin-converting enzyme 2 biological molecule biological molecules can be used coordination coronavirus CoV-19 COVID-19 delivery distribution domain dosage drug effective ENhance enzyme experiment experiments feasibility fraction Fractions gelatin gelatin stabilization generate IFN-α2 infection with SARS-CoV-2 inhalation inhalation therapy inhibit interferon lung Lungs medication nebulization noninvasive pandemic Protein protocol pulmonary pulmonary delivery. RBD-62 respiratory diseases SARS-CoV-2 significantly therapy transfer Vaccines variants [DOI] 10.1021/acsbiomaterials.2c00419 PMC 바로가기 [Article Type] Article
Pseudanabaena galeata CCNP1313-Biological Activity and Peptides ProductionPseudanabaena galeata CCNP1313-생물학적 활성 및 펩티드 생산Article Published on 2022-05-062022-09-11 Journal: Toxins [Category] COVID19(2023년), SARS, 치료기술, [키워드] A549 activity African green monkey analysis anticancer anticancer activity Antiviral antiviral activities antiviral activity Apoptosis Baltic Sea Breast cancer cancer cell line cancer cell lines cell line complex component Compound cyanobacteria cytotoxicity ecosystem Effect enzyme fibroblasts fraction Fractions green monkey HCoV HCoV-OC43 HCT-8 induction of apoptosis inhibitors kidney less MCF-7 metabolite metabolites new peptides. peptides potent produced Production Pseudanabaena galeata SARS-CoV-2 strain Structure tested TMPRSS2 toxins virus were used [DOI] 10.3390/toxins14050330 PMC 바로가기 [Article Type] Article
In-depth analysis of SARS-CoV-2-specific T cells reveals diverse differentiation hierarchies in vaccinated individualsSARS-CoV-2-특이적 T 세포에 대한 심층 분석은 백신 접종을 받은 개인의 다양한 분화 계층을 보여줍니다Article Published on 2022-04-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Adaptive immune response Adaptive immunity Analysis approach breadth Breakthrough infection breakthrough infections CD4+ T cell CD4+ T cells clinical trial clinical trials COVID-19 COVID-19 pandemic cytokine profile determinant effective Efficacy feature fraction Fractions identify IL-2 immune immunology immunology. indicate individual induce investigated Last Longevity magnitude majority mutant produced reactive recall Region responders reveal S-protein SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells T cell T cell response T cells TNF-α vaccinated individual vaccinated individuals vaccination Vaccine variants of concern [DOI] 10.1172/jci.insight.156559 PMC 바로가기 [Article Type] Article
Analysis of the Neutralizing Activity of Antibodies Targeting Open or Closed SARS-CoV-2 Spike Protein ConformationsArticle Published on 2022-02-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE2 activity analyzed binding binding affinity binding affinity prediction circulating complex conformation conformations contribute COVID-19 domains elicit elicited enzyme Epitopes escape fractions fraction Fractions immune response immunodominant immunogens immunoinformatics in silico infected patients information inhibit mRNA-1273 NAb neutralizing antibody Patient plasma polyclonal polyclonal plasma pre-fusion predict predicted Prevent SARS-CoV-2 SARS-COV-2 infection spike Spike protein Spike protein variants Strains Structure suggested target targeting the spike protein to define trajectory trimer Vaccine Vaccines variant virus [DOI] 10.3390/ijms23042078 PMC 바로가기 [Article Type] Article
Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method천연 MS 기반 친화성 선택 방법을 사용하여 허브 추출물에서 SARS-CoV-2 3C 유사 프로테아제에 대한 잠재적 억제제의 효율적인 발견Article Published on 2022-02-052022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL 3CL Protease 3CLpro acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied baicalein binding affinity characterized China Cirsium Complexes Compound compounds conducted Coronaviral coronavirus COVID-19 COVID-19 therapy Data acquisition Data processing Effectiveness efficient effort flavonoids Forsythia fraction Fractions Glycyrrhiza uralensis identify incubated Infection inhibitor investigated life cycle Ligand Lonicera japonica Native Native MS natural natural product outcomes protease protein-ligand resources SARS-CoV-2 scutellarein Scutellaria baicalensis severe acute respiratory syndrome Coronavirus small molecule Standard TCM therapy Traditional Chinese medicine traditional Chinese medicine. traditional Chinese medicines Treatment UHPLC Virus life cycle were used [DOI] 10.1016/j.jpba.2021.114538 PMC 바로가기 [Article Type] Article
Oral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular AspectsCOVID-19 및 SARS-CoV-2 감염의 구강 병리 - 분자 측면Review Published on 2022-01-272022-09-12 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aerosol Aerosols angiotensin angiotensin converting enzyme article aspect Cell cellular cellular damage Clinical sign Clinical signs contribute coronavirus COVID-19 COVID-19 transmission crevicular fluid data extraction database dental pulp Diagnosis enzyme epithelia evaluate Evidence Express Factor Factors Final Fractions furin Gingiva Health Organization infected patients Infection information Local molecular mucosa oral oral cavity oral mucosa performed periodontium produced Replication respiratory droplet Respiratory droplets Saliva salivary salivary gland SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 virus Serine severe acute respiratory syndrome Coronavirus Signs and symptoms Spread structures Symptom systemic infection the disease TMPRSS2 tongue transmembrane serine protease transmembrane serine protease 2 Transmission Treatment Type Vaccine virus virus infection virus particle virus particles were used World Health Organization [DOI] 10.3390/ijms23031431 PMC 바로가기 [Article Type] Review